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Title: Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors
Author: Li, HB ; Zhang, JC ; Xiong, WY ; Xu, TL(徐天乐) ; Cao, J ; Xu, L
Source: NEUROSCIENCE RESEARCH
Issued Date: 2005
Volume: 52, Issue:3, Pages:287-294
Keyword: long-term depression (LTD) ; subiculum ; muscarinic receptor ; G-protein ; calcium ; HIPPOCAMPAL PYRAMIDAL CELLS ; SYNAPTIC PLASTICITY ; CA1 REGION ; ALZHEIMERS-DISEASE ; IN-VITRO ; AREA CA1 ; MEMORY ; POTENTIATION ; ACETYLCHOLINE ; NEURONS
Subject: Neurosciences & Neurology
Corresponding Author: Cao, J (reprint author), Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Kunming 650223, Peoples R China,juncao@vip.163.com
English Abstract: The subiculum, which is the primary target of CA1 pyramidal neurons and sending efferent fibres to many brain regions, serves as a hippocampal interface in the neural information processes between hippocampal formation and neocortex. Long-term depression (LTD) is extensively studied in the hippocampus, but not at the CA1-subicular synaptic transmission. Using whole-cell EPSC recordings in the brain slices of young rats, we demonstrated that the pairing protocols of low frequency stimulation (LFS) at 3 Hz and postsynaptic depolarization of -50 mVelicited a reliable LTD in the subiculum. The LTD did not cause the changes of the paired-pulse ratio of EPSC. Furthermore, it did not depend on either NMDA receptors or voltage-gated calcium channels (VGCCs). Bath application of the G-protein coupled muscarinic acetylcholine receptors (mAChRs) antagonists, atropine or scopolamine, blocked the LTD, suggesting that mAChRs are involved in the LTD. It was also completely blocked by either the Ca2+ chelator BAPTA or the G-protein inhibitor GDP-beta-S in the intracellular solution. This type of LTD in the subiculum may play a particular role in the neural information processing between the hippocampus and neocortex. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1896
Appears in Collections:神经所(总)_期刊论文

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Li, HB; Zhang, JC; Xiong, WY; Xu, TL; Cao, J; Xu, L.Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors,NEUROSCIENCE RESEARCH,2005,52(3):287-294
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