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Title: Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons
Author: Xu, H ; Gong, N ; Chen, L ; Xu, TL(徐天乐)
Source: NEUROREPORT
Issued Date: 2005
Volume: 16, Issue:8, Pages:813-816
Keyword: gamma-aminobutyric acid type A receptor ; pain regulation ; spinal dorsal horn neurons ; sodium salicylate ; whole-cell patch-clamp ; ANTIINFLAMMATORY DRUGS ; INFERIOR COLLICULUS ; TINNITUS ; MECHANISM ; MODEL ; PAIN
Subject: Neurosciences & Neurology
Corresponding Author: Xu, TL (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
English Abstract: Sodium salicylate is one of the nonsteroidal antiinflammatory drugs and is clinically used for antiinflammation and chronic pain relief. In the present study, we investigated the actions of sodium salicylate on gamma-aminobutyric acid type A receptor (GABAA) current in cultured rat spinal dorsal horn neurons. Sodium salicylate was found to reduce GABAA current in a reversible and concentration-dependent manner, but did not change its ion selectivity. Sodium salicylate was effective only when GABA and sodium salicylate were applied together. Application of sodium salicylate immediately before, but not during, the application of GABA did not result in a significant reduction of GABAA current. Our results demonstrate that sodium salicylate reversibly attenuates the GABAA response of dorsal horn neurons, suggesting that GABAA receptors in the region are pharmacological targets of sodium salicylate. NeuroReport 16:813-816 (c) 2005 Lippincott Williams & Wilkins.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1902
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Xu, H; Gong, N; Chen, L; Xu, TL.Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons,NEUROREPORT,2005,16(8):813-816
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