Xu, TL (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China,email@example.com
Sodium salicylate is one of the nonsteroidal antiinflammatory drugs and is clinically used for antiinflammation and chronic pain relief. In the present study, we investigated the actions of sodium salicylate on gamma-aminobutyric acid type A receptor (GABAA) current in cultured rat spinal dorsal horn neurons. Sodium salicylate was found to reduce GABAA current in a reversible and concentration-dependent manner, but did not change its ion selectivity. Sodium salicylate was effective only when GABA and sodium salicylate were applied together. Application of sodium salicylate immediately before, but not during, the application of GABA did not result in a significant reduction of GABAA current. Our results demonstrate that sodium salicylate reversibly attenuates the GABAA response of dorsal horn neurons, suggesting that GABAA receptors in the region are pharmacological targets of sodium salicylate. NeuroReport 16:813-816 (c) 2005 Lippincott Williams & Wilkins.