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Title: Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor
Author: Li, Y ; Jia, YC ; Cui, K ; Li, N ; Zheng, ZY ; Wang, YZ ; Yuan, XB
Source: NATURE
Issued Date: 2005
Volume: 434, Issue:7035, Pages:894-898
Keyword: PHOSPHOLIPASE-C ; CATION CHANNELS ; AXON GUIDANCE ; CELLS ; RECEPTORS ; ACTIVATION ; INHIBITOR ; CURRENTS ; FAMILY ; BDNF
Subject: Science & Technology - Other Topics
Corresponding Author: Yuan, XB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn ; yuanxb@ion.ac.cn
English Abstract: Brain-derived neurotrophic factor ( BDNF) is known to promote neuronal survival and differentiation(1) and to guide axon extension both in vitro(2,3) and in vivo(4). The BDNF-induced chemoattraction of axonal growth cones requires Ca2+ signalling(3), but how Ca2+ is regulated by BDNF at the growth cone remains largely unclear. Extracellular application of BDNF triggers membrane currents resembling those through TRPC ( transient receptor potential canonical) channels in rat pontine neurons(5) and in Xenopus spinal neurons(6). Here, we report that in cultured cerebellar granule cells, TRPC channels contribute to the BDNF-induced elevation of Ca2+ at the growth cone and are required for BDNF-induced chemo-attractive turning. Several members of the TRPC family are highly expressed in these neurons, and both Ca2+ elevation and growth-cone turning induced by BDNF are abolished by pharmacological inhibition of TRPC channels, overexpression of a dominant-negative form of TRPC3 or TRPC6, or downregulation of TRPC3 expression via short interfering RNA. Thus, TRPC channel activity is essential for nerve-growth-cone guidance by BDNF.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1911
Appears in Collections:神经所(总)_期刊论文

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Li, Y; Jia, YC; Cui, K; Li, N; Zheng, ZY; Wang, YZ; Yuan, XB.Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor,NATURE,2005,434(7035):894-898
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