中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Ca2+-dependent regulation of Rho GTPases triggers turning of nerve growth cones
Author: Jin, M ; Guan, CB ; Jiang, YA ; Chen, G ; Zhao, CT ; Cui, K ; Song, YQ ; Wu, CP ; null(蒲慕明) ; Yuan, XB
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2005
Volume: 25, Issue:9, Pages:2338-2347
Keyword: axon guidance ; growth cone ; Rho GTPases ; calcium ; PKC ; CaMKII ; PROTEIN-KINASE-C ; SIGNAL-TRANSDUCTION ; DIFFUSIBLE FACTORS ; CALCIUM CURRENT ; NOGO RECEPTOR ; AXON GUIDANCE ; ACTIVATION ; CELLS ; CDC42 ; RAC
Subject: Neurosciences & Neurology
Corresponding Author: Poo, MM (reprint author), Univ Calif Berkeley, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA,mpoo@uclink.berkeley.edu ; yuanxb@ion.ac.cn
English Abstract: Cytoplasmic Ca2+ elevation and changes in Rho GTPase activity are both known to mediate axon guidance by extracellular factors, but the causal relationship between these two events has been unclear. Here we show that direct elevation of cytoplasmic Ca2+ by extracellular application of a low concentration of ryanodine, which activated Ca2+ release from intracellular stores, upregulated Cdc42/Rac, but downregulated RhoA, in cultured cerebellar granule cells and human embryonic kidney 293T cells. Chemoattractive turning of the growth cone triggered by a gradient of ryanodine was blocked by overexpression of mutant forms of Cdc42 but not of RhoA in Xenopus spinal cord neurons. Furthermore, Ca2+-induced GTPase activity correlated with activation of protein kinase C and required a basal activity of Ca2+/calmodulin-dependent protein kinase II. Thus, Rho GTPases may mediate axon guidance by linking upstream Ca2+ signals triggered by guidance factors to downstream cytoskeletal rearrangements.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1916
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Jin-2005-Ca2+-dependent regul.pdf(1013KB)----开放获取View Download

Recommended Citation:
Jin, M; Guan, CB; Jiang, YA; Chen, G; Zhao, CT; Cui, K; Song, YQ; Wu, CP; Poo, MM; Yuan, XB.Ca2+-dependent regulation of Rho GTPases triggers turning of nerve growth cones,JOURNAL OF NEUROSCIENCE,2005,25(9):2338-2347
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jin, M]'s Articles
[Guan, CB]'s Articles
[Jiang, YA]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jin, M]‘s Articles
[Guan, CB]‘s Articles
[Jiang, YA]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Jin-2005-Ca2+-dependent regul.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!