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Title: Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3 beta and its upstream regulators
Author: Jiang, H ; Guo, W ; Liang, XH ; Rao, Y
Source: CELL
Issued Date: 2005
Volume: 120, Issue:1, Pages:123-135
Keyword: GLYCOGEN-SYNTHASE KINASE-3 ; CULTURED HIPPOCAMPAL-NEURONS ; DISPERSED CELL-CULTURE ; PROTEIN-KINASE ; GROWTH CONES ; TUMOR-SUPPRESSOR ; AXON FORMATION ; PHOSPHORYLATION ; INHIBITION ; TAU
Subject: Biochemistry & Molecular Biology ; Cell Biology
Corresponding Author: Rao, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Grad Sch, 320 Yueyang Rd, Shanghai 200031, Peoples R China,y-rao@northwestem.edu
English Abstract: Axon-dendrite polarity is a cardinal feature of neuronal morphology essential for information flow. Here we report a differential distribution of GSK-3beta activity in the axon versus the dendrites. A constitutively active GSK-3beta mutant inhibited axon formation, whereas multiple axons formed from a single neuron when GSK-3beta activity was reduced by pharmacological inhibitors, a peptide inhibitor, or siRNAs. An active mechanism for maintaining neuronal polarity was revealed by the conversion of preexisting dendrites into axons upon GSK-3 inhibition. Biochemical and functional data show that the Akt kinase and the PTEN phosphatase are upstream of GSK-3beta in determining neuronal polarity. Our results demonstrate that there are active mechanisms for maintaining as well as establishing neuronal polarity, indicate that GSK-3beta relays signaling from Akt and PTEN to play critical roles in neuronal polarity, and suggest that application of GSK-3beta inhibitors can be a novel approach to promote generation of new axons after neural injuries.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1924
Appears in Collections:神经所(总)_期刊论文

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Jiang, H; Guo, W; Liang, XH; Rao, Y.Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3 beta and its upstream regulators,CELL,2005,120(1):123-135
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