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Title: Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion
Author: Yu, WY ; Guo, W ; Feng, LY
Source: FEBS LETTERS
Issued Date: 2004
Volume: 577, Issue:40910, Pages:87-92
Keyword: lipid raft ; Nogo66 ; Nogo66 receptor ; p75 ; signal transduction ; cholesterol depletion ; MYELIN-ASSOCIATED GLYCOPROTEIN ; CELL-ADHESION MOLECULES ; NERVE GROWTH CONES ; NEURITE OUTGROWTH ; NOGO-66 RECEPTOR ; DEPENDENT RECRUITMENT ; AXONAL REGENERATION ; ANCHORED PROTEINS ; MEMBRANE DOMAINS ; P75 RECEPTOR
Subject: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
Corresponding Author: Feng, LY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China,lyfeng@sibs.ac.cn
English Abstract: NogoA, a myelin-associated component, inhibits neurite outgrowth. Nogo66, a portion of NogoA, binds to Nogo66 receptor (NgR) and induces the inhibitory signaling. LINGO-1 and p75 neurotrophin receptor (p75), the low-affinity nerve growth factor receptor, are also required for NogoA signaling. However, signaling mechanisms downstream to Nogo receptor remain poorly understood. Here, we observed that NgR and p75 were colocalized in low-density membrane raft fractions derived from forebrains and cerebella as well as from cerebellar granule cells. NgR interacted with p75 in lipid rafts. In addition, disruption of lipid rafts by beta-methylcyclodextrin, a cholesterol-binding reagent, reduced the Nogo66 signaling. Our results suggest an important role of lipid rafts in facilitating the interaction between NgRs and provide insight into mechanisms underlying the inhibition of neurite outgrowth by NogoA. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1936
Appears in Collections:神经所(总)_期刊论文

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Yu, WY; Guo, W; Feng, LY.Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion,FEBS LETTERS,2004,577(40910):87-92
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