中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Conus peptides - A rich pharmaceutical treasure
Author: Wang, CZ ; Chi, CW
Source: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Issued Date: 2004
Volume: 36, Issue:11, Pages:713-723
Keyword: Conus peptide ; conotoxin ; neuropathic disorder ; pharmaceutical potency ; K-DEPENDENT CARBOXYLASE ; SODIUM-CHANNELS ; ION-CHANNEL ; CALCIUM-CHANNEL ; VENOM PEPTIDES ; CONANTOKIN-G ; DRUG DESIGN ; CONOTOXIN ; SNAILS ; RECEPTOR
Subject: Biochemistry & Molecular Biology ; Biophysics
Corresponding Author: Chi, CW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China,chi@sumn.shcnc.ac.cn
English Abstract: Marine predatory cone snails (genus Conus) with over 500 species represent what is arguably the largest single genus of marine animals alive today. All Conus are venomous and utilize a complex mixture of Conus peptides to capture their preys and for other biological purposes. Each component of Conus peptides selectively targets a specific subtype of ion channels, neurotransmitter receptors or transporters. Owing to their diversity, more than 50,000 distinct active peptides are theoretically estimated in Conus venoms. These diversified toxins are generally categorized into several superfamilies and/or families based on their characteristic arrangements of cysteine residues and pharmacological actions. Some mechanisms underlying the remarkable diversity of Conus peptides have been postulated: the distinctive gene structure, gene duplication and/or allelic selection, genus speciation, and sophisticated expression pattern and post-translational modification of these peptides. Due to their highly pharmacological potency and target selectivity, Conus peptides have attracted extensive attention with their potentials to be developed as new research tools in neuroscience field and as novel medications in clinic for pain, epilepsy and other neuropathic disorders. Several instructive lessons for our drug development could be also learnt from these neuropharmacological "expertises". Conus peptides comprise a rich resource for neuropharmacologists, and most of them await to be explored.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1937
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Wang-2004-Conus peptides - A r.pdf(527KB)----开放获取View Download

Recommended Citation:
Wang, CZ; Chi, CW.Conus peptides - A rich pharmaceutical treasure,ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2004,36(11):713-723
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, CZ]'s Articles
[Chi, CW]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, CZ]‘s Articles
[Chi, CW]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Wang-2004-Conus peptides - A r.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!