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Title: Development of the mouse retina: Emerging morphological diversity of the ganglion cells
Author: Diao, L ; Sun, WZ ; Deng, QD ; He, SG
Source: JOURNAL OF NEUROBIOLOGY
Issued Date: 2004
Volume: 61, Issue:2, Pages:236-249
Keyword: dendritic field ; branching pattern ; stratification ; DiI ; gene gun ; MEDIATED AFFERENT ACTIVITY ; RABBIT RETINA ; CAT RETINA ; DENDRITIC STRATIFICATION ; ALPHA-GANGLION ; INNER RETINA ; MATURATION ; RAT ; MICE ; BETA
Subject: Neurosciences & Neurology
Corresponding Author: He, SG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,s.he@ion.ac.cn
English Abstract: The time course and regulatory mechanisms of dendritic development are subjects of intense interest. We approached these problems by investigating dendritic morphology of retinal ganglion cells (RGCs) at four early postnatal stages. The RGCs develop from a diffusely stratified and poorly differentiated group at birth (P0), to 16 distinct, morphologically well-defined subtypes before eye opening (P13). Even before bipolar cells make synaptic contacts with the RGCs (P8), most adultlike RGC subtypes are already present. Similar to previous studies in other mammalian species, our results indicate that the initiation of the RGC morphological maturation is independent of light stimulation and of formation of glutamatergic synapses. This study narrowed down the window of RGCs morphological maturation and highlighted a few early postnatal events as potential factors controlling the developmental process. Because mouse is the most popular mammalian model for genetic manipulation, this study provided a foundation for further exploring regulatory mechanisms of RGC dendritic development. (C) 2004 Wiley Periodicals, Inc.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1939
Appears in Collections:神经所(总)_期刊论文

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Diao, L; Sun, WZ; Deng, QD; He, SG.Development of the mouse retina: Emerging morphological diversity of the ganglion cells,JOURNAL OF NEUROBIOLOGY,2004,61(2):236-249
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