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Title: Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway
Author: Lai, C ; Feng, LY
Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Issued Date: 2004
Volume: 319, Issue:2, Pages:603-611
Keyword: neural progenitor cell ; neuregulin ; proliferation ; PLC ; PKQ ; TPA ; ACTIVATED PROTEIN-KINASE ; FIBROBLAST-GROWTH-FACTOR ; STEM-CELLS ; NEUROTROPHIC FACTOR ; PHOSPHOLIPASE-C ; CORTICAL-NEURONS ; EPITHELIAL-CELLS ; PRECURSOR CELLS ; CANCER CELLS ; MAP KINASE
Subject: Biochemistry & Molecular Biology ; Biophysics
Corresponding Author: Feng, LY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China,lyfeiig@sibs.ac.cn
English Abstract: Nestin-expressing neural progenitor cells (NPCs) have been isolated from hippocampus of brains and propagated with epidermal growth factor and basic fibroblast growth factor (bFGF). However, the underlying signaling mechanisms regulating NPC proliferation remain elusive. Here we showed that neuregulinbeta1 (NRG), like bFGF, effectively promoted the proliferation of hippocampus-derived NPCs and maintained the progenitor states of NPCs. Activation of protein kinase C (PKC), a downstream effector of phospholipase C (PLC), with 12-O-tetradecanoylphorbol-13-acetate (TPA) mimicked the NRG-induced proliferation of NPCs. The synergic effect of TPA plus NRG on neurosphere growth further prompted us to find that NRG induced NPC propagation through PLC/PKC signaling pathway. ErbB4, an important functional receptor of NRG, had an interaction with PLCgamma1 protein. In addition, inactivation of PLC pathway led to severe proliferative suppression of NPCs. Our study suggests that activation of PLC/PKC pathway plays an essential role in the NRG-induced proliferation of hippocampus-derived NPCs. (C) 2004 Elsevier Inc. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1955
Appears in Collections:神经所(总)_期刊论文

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Lai, C; Feng, LY.Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,319(2):603-611
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