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Title: Ion channels mediate proton transduction in peripheral pain perception
Author: Wu, LJ ; Xu, TL(徐天乐)
Source: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
Issued Date: 2004
Volume: 31, Issue:5, Pages:393-397
Keyword: pain ; tissue acidosis ; ion channels ; CAPSAICIN RECEPTOR ; P2X RECEPTORS ; MICE LACKING ; K+ CHANNEL ; NEURONS ; RAT ; NOCICEPTION ; STIMULI ; FAMILY ; PH
Subject: Biochemistry & Molecular Biology ; Biophysics
Alternative Title: 组织酸化参与外周痛觉传递的离子通道机制
Corresponding Author: Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
English Abstract: Tissue acidosis can directly induce pain sensation which is mediated by ion channels in peripheral sensory neurons. To date, several ion channel superfamilies are identified to be involved in the pain from tissue acidosis. ( 1) ASICs can be gated by proton and directly mediate the acidosis pain; (2) VR1 can be sensitized by acidosis as well as activated by pH < 6.0; (3) P2X2 receptor is up-modulated whereas P2X3 is down-modulated by acidosis; (4) TASK is one of the tandem pore and the inwardly rectifying K+ channel which can be closed by acidosis.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1963
Appears in Collections:神经所(总)_期刊论文

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Wu, LJ; Xu, TL.Ion channels mediate proton transduction in peripheral pain perception,PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2004,31(5):393-397
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