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Title: Corticofugal Gating of auditory information in the thalamus: An in vivo intracellular recording study
Author: Yu, YQ ; Xiong, Y ; Chan, YS ; He, JF
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2004
Volume: 24, Issue:12, Pages:3060-3069
Keyword: corticofugal modulation ; the medial geniculate body ; electrical stimulation ; in vivo intracellular recording ; excitatory postsynaptic potential ; EPSP ; inhibitory postsynaptic potential ; IPSP ; low-threshold calcium spike ; MEDIAL GENICULATE-BODY ; NUCLEUS RETICULARIS THALAMI ; BIG BROWN BAT ; CORTICOTHALAMIC PROJECTIONS ; RECEPTOR ACTIVATION ; CELLULAR MECHANISMS ; INFERIOR COLLICULUS ; CORTICAL ACTIVATION ; MAMMALIAN THALAMUS ; SOUND STIMULATION
Subject: Neurosciences & Neurology
Corresponding Author: He, JF (reprint author), Hong Kong Polytech Univ, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China,rsjufang@polyu.edu.hk
English Abstract: In the present study, we investigated the auditory responses of the medial geniculate (MGB) neurons, through in vivo intracellular recordings of anesthetized guinea pigs, while the auditory cortex was electrically activated. Of the 63 neurons that received corticofugal modulation of the membrane potential, 30 received potentiation and 33 received hyperpolarization. The corticofugal potentiation of the membrane potential (amplitude, mean +/- SD, 8.6 +/- 5.5 mV; duration, 125.5 +/- 75.4 msec) facilitated the auditory responses and spontaneous firing of the MGB neurons. The hyperpolarization of - 11.3 +/- 4.9 mV in amplitude and 210.0 +/- 210.1 msec in duration suppressed the auditory responses and spontaneous firing of the MGB neurons. Four of the five neurons that were histologically confirmed to be located in the lemniscal MGB received corticofugal facilitatory modulation, and all of the four neurons that were confirmed to be located in the non-lemniscal MGB received corticofugal inhibitory modulation. The present intracellular recording provides novel results on how the corticofugal projection gates the sensory information in the thalamus: via the spatially selective depolarization of lemniscal MGB neurons and hyperpolarization of non-lemniscal MGB neurons. It is speculated that the systematic selectivity of facilitation and inhibition over the lemniscal and non-lemniscal MGB is related to the attention shift within the auditory modality and across the sensory modalities.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1970
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Yu, YQ; Xiong, Y; Chan, YS; He, JF.Corticofugal Gating of auditory information in the thalamus: An in vivo intracellular recording study,JOURNAL OF NEUROSCIENCE,2004,24(12):3060-3069
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