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Title: Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration
Author: Xu, HT ; Yuan, XB ; Guan, CB ; Duan, SM ; Wu, CP ; Feng, LY
Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Issued Date: 2004
Volume: 101, Issue:12, Pages:4296-4301
Keyword: NERVE GROWTH CONES ; INTRACELLULAR CA2+ FLUCTUATIONS ; TRANSIENTS ; GUIDANCE ; CELLS ; RECEPTORS ; SYSTEM ; MODULATION ; CHEMOTAXIS ; ACTIVATION
Subject: Science & Technology - Other Topics
Corresponding Author: Feng, LY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,lyfeng@ion.ac.cn
English Abstract: Migration of neuronal precursor cells in the developing brain is guided by extracellular cues, but intracellular signaling processes underlying the guidance of neuronal migration are largely unknown. By examining the migration of cerebellar granule neurons along the surface of cocultured astroglial cells, we found that an extracellular gradient of Slit2, a chemorepellant for neuronal migration in vivo, caused a reversal in the direction of migration without affecting the migration speed. A Slit2 gradient elevated the intracellular concentration of Ca2+, probably due to calcium release from the internal store, led to a reversal of the preexisting asymmetric intracellular Ca2+ distribution in the soma of migrating neurons, and this reversal was closely related with its action of reversing the migrating direction. Asymmetric Ca2+ distribution in the soma was both necessary and sufficient for directing neuronal migration. These results have demonstrated an important role for Ca2+ in mediating neuronal responses to Slit2 and suggest a general mechanism for neuronal guidance.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1972
Appears in Collections:神经所(总)_期刊论文

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Xu, HT; Yuan, XB; Guan, CB; Duan, SM; Wu, CP; Feng, LY.Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2004,101(12):4296-4301
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