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Title: Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes
Author: Lai, C ; Feng, LY
Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Issued Date: 2004
Volume: 314, Issue:2, Pages:535-542
Keyword: ErbB4 ; neuregulin ; gamma-secretase ; nuclear translocation ; oligodendrocyte ; maturation ; myelination ; MYELINATING SCHWANN-CELLS ; YES-ASSOCIATED PROTEIN ; SIGNAL-TRANSDUCTION ; PRECURSOR CELLS ; TYROSINE KINASE ; DENTATE GYRUS ; GROWTH-FACTOR ; ADULT-RAT ; IN-VITRO ; PROLIFERATION
Subject: Biochemistry & Molecular Biology ; Biophysics
Corresponding Author: Feng, LY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,lyfeng@sibs.ac.cn
English Abstract: Increasing evidences suggest that, after neuregulin (NRG) stimulation, ErbB34 undergoes a series of proteolysis, including gamma-secretase cleavage. The released ErbB4 intracellular domain (EICD) is translocated into nucleus and has a transcriptional function. Although NRG-ErbB4 signaling mediates maturation of oligodendrocytes (OLs), the role of EICD and gamma-secretase in this process remains elusive. Here, we showed that NRG-ErbB4 interaction accumulated EICD in the nucleus and promoted the expression of myelin basic protein expression in OLs. Conversely, inhibitor of ErbB34 or gamma-secretase blocked the capacity of NRG. Nuclear accumulation of EICD did not influence maturation of neurons and astrocytes and early development of OLs. We also found that EICD translocation accorded a temporal pattern, consistent with the developmental gradient of hippocampus. Our data suggest that gamma-secretase activation and EICD nuclear translocation are required for OL maturation induced by NRG, and ErbB4 acts as a functional receptor depending on a new signaling cascade. (C) 2003 Elsevier Inc. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1975
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Lai, C; Feng, LY.Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,314(2):535-542
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