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Title: Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticity
Author: null(李澄宇) ; Lu, JT ; Wu, CP ; Duan, SM ; null(蒲慕明)
Source: NEURON
Issued Date: 2004
Volume: 41, Issue:2, Pages:257-268
Keyword: LONG-TERM POTENTIATION ; PROTEIN-KINASE-C ; HIPPOCAMPAL PYRAMIDAL CELLS ; SPINY STELLATE NEURONS ; INTRINSIC EXCITABILITY ; BARREL CORTEX ; POTASSIUM CURRENTS ; NEURAL-NETWORKS ; K+ CHANNELS ; ACTIVATION
Subject: Neurosciences & Neurology
Corresponding Author: Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,shumin@ion.ac.cn ; rnpoo@uclink.berkeley.edu
English Abstract: Correlated pre- and postsynaptic activity that induces long-term potentiation is known to induce a persistent enhancement of the intrinsic excitability of the presynaptic neuron. Here we report that, associated with the induction of long-term depression in hippocampal cultures and in somatosensory cortical slices, there is also a persistent reduction in the excitability of the presynaptic neuron. This reduction requires postsynaptic Ca2+ elevation and presynaptic PKA- and PKC-dependent modification of slow-inactivating K+ channels. The bidirectional changes in neuronal excitability and synaptic efficacy exhibit identical requirements for the temporal order of pre- and postsynaptic activation but reflect two distinct aspects of activity-induced modification of neural circuits.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1982
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

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Recommended Citation:
Li, CY; Lu, JT; Wu, CP; Duan, SM; Poo, MM.Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticity,NEURON,2004,41(2):257-268
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