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Title: ATP released by Astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression
Author: Zhang, JM ; Wang, HK ; Ye, CQ ; Ge, WP ; Chen, YR ; Jiang, ZL ; Wu, CP ; null(蒲慕明) ; Duan, SM
Source: NEURON
Issued Date: 2003
Volume: 40, Issue:5, Pages:971-982
Keyword: RAT SPINAL-CORD ; DORSAL-HORN NEURONS ; CALCIUM WAVES ; HIPPOCAMPAL ASTROCYTES ; SYNAPTIC TRANSMISSION ; IN-VITRO ; RECEPTORS ; INHIBITION ; ACTIVATION ; ADENOSINE
Subject: Neurosciences & Neurology
Corresponding Author: Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,
English Abstract: Extracellular ATIP released from axons is known to assist activity-dependent signaling between neurons and Schwann cells in the peripheral nervous system. Here we report that ATP released from astrocytes as a result of neuronal activity can also modulate central synaptic transmission. In cultures of hippocampal neurons, endogenously released ATP tonically suppresses glutamatergic synapses via presynaptic P2Y receptors, an effect that depends on the presence of cocultured astrocytes. Glutamate release accompanying neuronal activity also activates non-NMDA receptors of nearby astrocytes and triggers ATIP release from these cells, which in turn causes homo- and heterosynaptic suppression. In CA1 pyramidal neurons of hippocampal slices, a similar synaptic suppression was also produced by adenosine, an immediate degradation product of ATIP released by glial cells. Thus, neuron-glia crosstalk may participate in activity-dependent synaptic modulation.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1989
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

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Recommended Citation:
Zhang, JM; Wang, HK; Ye, CQ; Ge, WP; Chen, YR; Jiang, ZL; Wu, CP; Poo, MM; Duan, SM.ATP released by Astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression,NEURON,2003,40(5):971-982
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