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Title: Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx
Author: Du, J ; Feng, LY ; Zaitsev, E ; Je, HS ; Liu, XW ; Lu, B
Source: JOURNAL OF CELL BIOLOGY
Issued Date: 2003
Volume: 163, Issue:2, Pages:385-395
Keyword: BDNF ; endocytosis ; calcium influx ; hippocampus ; activity dependent ; NERVE GROWTH-FACTOR ; DEVELOPING NEUROMUSCULAR SYNAPSES ; NEUROTROPHIN SIGNAL-TRANSDUCTION ; HIPPOCAMPAL-NEURONS ; SYMPATHETIC NEURONS ; RETROGRADE SIGNAL ; PLASMA-MEMBRANE ; POTENTIATION ; ENDOCYTOSIS ; CLATHRIN
Subject: Cell Biology
Corresponding Author: Lu, B (reprint author), NICHD, Sect Neural Dev & Plast, Lab Cellular & Synapt Neurophysiol, NIH, Bldg 49,Rm 6A80,49 Convent Dr, Bethesda, MD 20892 USA,
English Abstract: Internalization of the neurotrophin-Trk receptor complex is critical for many aspects of neurotrophin functions. The mechanisms governing the internalization process are unknown. Here, we report that neuronal activity facilitates the internalization of the receptor for brain-derived neurotrophic factor, TrkB, by potentiating its tyrosine kinase activity. Using three independent approaches, we show that electric stimulation of hippocampal neurons markedly enhances TrkB internalization. Electric stimulation also potentiates TrkB tyrosine kinase activity. The activity-dependent enhancement of TrkB internalization and its tyrosine kinase requires Ca2+ influx through N-methyl-D-aspartate receptors and Ca2+ channels. inhibition of internalization had no effect on TrkB kinase, but inhibition of TrkB kinase prevents the modulation of TrkB internalization, suggesting a critical role of the tyrosine kinase in the activity-dependent receptor endocytosis. These results demonstrate an activity and Ca2+-dependent modulation of TrkB tyrosine kinase and its internalization, and they provide new insights into the cell biology of tyrosine kinase receptors.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1996
Appears in Collections:神经所(总)_期刊论文

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Du, J; Feng, LY; Zaitsev, E; Je, HS; Liu, XW; Lu, B.Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx,JOURNAL OF CELL BIOLOGY,2003,163(2):385-395
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