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Title: Amiloride inhibition of glycinergic miniature IPSCs in mechanically dissociated rat spinal neurons
Author: Li, Y ; Li, YF ; Xu, TL(徐天乐)
Source: NEUROSCIENCE LETTERS
Issued Date: 2003
Volume: 349, Issue:1, Pages:17-20
Keyword: amiloride ; transmission ; glycinergic miniature IPSCs ; glycine receptor ; whole-cell recording ; spinal dorsal horn neurons ; NA+ CHANNEL ; ANALOGS ; RECEPTORS ; TRANSPORT ; TOOLS ; BRAIN
Subject: Neurosciences & Neurology
Corresponding Author: Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,
English Abstract: The effect of amiloride on glycinergic transmission in mechanically dissociated rat spinal dorsal horn neurons was examined with the use of whole-cell patch-clamp recording. Amiloride reversibly reduced both the frequency and amplitude of spontaneous glycinergic miniature IPSCs (mIPSCs) and its inhibitory effect on glycinergic rnIPSCs persisted in either Ca2+-free or Na+-free external solutions while it disappeared in K+-free external solution. Analysis of the relationship between rnIPSCs aniplitude and frequency at various holding potentials shows that amiloride inhibition of glycinergic rnIPSC frequency could result indirectly from its inhibition of amplitude. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2004
Appears in Collections:神经所(总)_期刊论文

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Li, Y; Li, YF; Xu, TL.Amiloride inhibition of glycinergic miniature IPSCs in mechanically dissociated rat spinal neurons,NEUROSCIENCE LETTERS,2003,349(1):17-20
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