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Title: Inhibition of glycine response by amiloride in rat spinal neurons
Author: Li, YF ; Li, Y ; Xu, TL(徐天乐)
Source: NEUROSCIENCE LETTERS
Issued Date: 2003
Volume: 345, Issue:3, Pages:173-176
Keyword: amiloride ; glycine receptor ; GABA(A) receptor ; Cl- channel ; interaction ; spinal dorsal horn neurons ; DORSAL COMMISSURAL NEURONS ; NA+ CHANNEL ; RECEPTORS ; ANALOGS ; TRANSPORT ; TOOLS ; BRAIN
Subject: Neurosciences & Neurology
Corresponding Author: Xu, TL (reprint author), Univ Sci & Technol, Dept Neurobiol & Biophys, Hefei 230027, Peoples R China,
English Abstract: The modulatory effect of amiloride on glycine-activated current (I-Gly) was investigated in acutely dissociated rat spinal dorsal horn neurons using the whole-cell patch clamp technique. Amiloride inhibited I-Gly reversibly in a concentration-dependent manner. It shifted the concentration-response relationship to the right without altering the maximum response and Hill coefficient of the I-Gly. Amiloride did not change the ion selectivity of glycine receptor either. In addition, Na+- or Ca2+-free extracellular solutions and intracellular application of amiloride did not alter the amiloride inhibition of I-Gly. These results indicate that amiloride directly inhibited the glycine receptor response by decreasing the affinity of glycine to its receptor. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2013
Appears in Collections:神经所(总)_期刊论文

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Li, YF; Li, Y; Xu, TL.Inhibition of glycine response by amiloride in rat spinal neurons,NEUROSCIENCE LETTERS,2003,345(3):173-176
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