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Title: Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity
Author: Wang, B ; Xiao, Y ; Ding, BB ; Zhang, N ; Yuan, XB ; Gui, L ; Qian, KX ; Duan, SM ; Chen, ZJ ; Rao, Y ; Geng, JG
Source: CANCER CELL
Issued Date: 2003
Volume: 4, Issue:1, Pages:19-29
Keyword: REPULSIVE AXON GUIDANCE ; NEURONAL MIGRATION ; HEPARAN-SULFATE ; LEUKOCYTE CHEMOTAXIS ; VERTEBRATE SLIT ; P-SELECTIN ; PROTEIN ; DROSOPHILA ; ADHESION ; RECEPTORS
Subject: Oncology ; Cell Biology
Corresponding Author: Geng, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Beijing 200031, Peoples R China,
English Abstract: Slit is a secreted protein known to function through the Roundabout (Robo) receptor as a chemorepellent in axon guidance and neuronal migration, and as an inhibitor in leukocyte chemotaxis. Here we show Slit2 expression in a large number of solid tumors and Robo1 expression in vascular endothelial cells. Recombinant Slit2 protein attracted endothelial cells and promoted tube formation in a Robo1- and phosphatidylinositol kinase-dependent manner. Neutralization of Robo1 reduced the microvessel density and the tumor mass of human malignant melanoma A375 cells in vivo. These findings demonstrate the angiogenic function of Slit-Robo signaling, reveal a mechanism in mediating the crosstalk between cancer cells and endothelial cells, and indicate the effectiveness of blocking this signaling pathway in treating cancers.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2015
Appears in Collections:神经所(总)_期刊论文

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Wang, B; Xiao, Y; Ding, BB; Zhang, N; Yuan, XB; Gui, L; Qian, KX; Duan, SM; Chen, ZJ; Rao, Y; Geng, JG.Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity,CANCER CELL,2003,4(1):19-29
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