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Title: Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts
Author: Ma, L ; Huang, YZ ; Pitcher, GM ; Valtschanoff, JG ; Ma, YH ; Feng, LY ; Lu, B ; Xiong, WC ; Salter, MW ; Weinberg, RJ ; Mei, L
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2003
Volume: 23, Issue:8, Pages:3164-3175
Keyword: lipid rafts ; ErbB4 ; NRG ; PSD-95 ; postsynaptic density ; long-term potentiation ; synaptic plasticity ; RECEPTOR GENE-EXPRESSION ; SOMATIC SENSORY CORTEX ; LONG-TERM POTENTIATION ; NERVOUS-SYSTEM ; POSTSYNAPTIC DENSITY ; NEUREGULIN RECEPTOR ; NEUROMUSCULAR-JUNCTION ; TRANSMEMBRANE DOMAIN ; HIPPOCAMPAL-NEURONS ; CONTAINING PROTEINS
Subject: Neurosciences & Neurology
Corresponding Author: Mei, L (reprint author), Univ Alabama, Sch Med, Dept Neurobiol, Civitan Int Res Ctr 516, 1719 6th Ave S, Birmingham, AL 35294 USA,
English Abstract: Neuregulin (NRG) regulates synapse formation and synaptic plasticity, but little is known about the regulation of NRG signaling at synapses. Here we show that the NRG receptor ErbB4 was localized in anatomically defined postsynaptic densities in the brain. In cultured cortical neurons, ErbB4 was recruited to the neuronal lipid raft fraction after stimulation by NRG. Along with ErbB4, adaptor proteins Grb2 and Shc were translocated to lipid rafts by NRG stimulation. In transfected human embryonic kidney 293 cells, the partitioning of ErbB4 into a detergent-insoluble fraction that includes lipid rafts was increased by PSD-95 ( postsynaptic density-95), through interaction of the ErbB4 C terminus with the PDZ [PSD-95/Discs large/zona occludens-1] domains of PSD-95. Disruption of lipid rafts inhibited NRG-induced activation of Erk and prevented NRG-induced blockade of induction of long-term potentiation at hippocampal CA1 synapses. Thus, our results indicate that NRG stimulation causes translocation of ErbB4 into lipid rafts and that lipid rafts are necessary for signaling by ErbB4.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2021
Appears in Collections:神经所(总)_期刊论文

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Ma, L; Huang, YZ; Pitcher, GM; Valtschanoff, JG; Ma, YH; Feng, LY; Lu, B; Xiong, WC; Salter, MW; Weinberg, RJ; Mei, L.Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts,JOURNAL OF NEUROSCIENCE,2003,23(8):3164-3175
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