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Title: Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat
Author: Lou, XL ; Yu, X ; Chen, XK ; Duan, KL ; He, LM ; Qu, AL ; Xu, T ; Zhou, Z
Source: JOURNAL OF PHYSIOLOGY-LONDON
Issued Date: 2003
Volume: 548, Issue:1, Pages:191-202
Keyword: B-CELLS ; INSULIN-SECRETION ; ACTION-POTENTIALS ; PATCH-CLAMP ; QUANTAL SECRETION ; POTASSIUM CHANNEL ; IONIC CURRENTS ; CA2+ CURRENT ; CALCIUM ; SODIUM
Subject: Neurosciences & Neurology ; Physiology
Corresponding Author: Zhou, Z (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,
English Abstract: A comparative study was carried out on the inactivation of Na+ channels in two types of endocrine cells in rats, beta-cells and adrenal chromaffin cells (ACCs), using patch-clamp techniques. The beta-cells were very sensitive to hyperpolarization; the Na+ currents increased ninefold when the holding potential was shifted from -70 mV to -120 mV. ACCs were not sensitive to hyperpolarization. The half-inactivation voltages were -90 mV (rat beta-cells) and -62 mV (ACCs). The time constant for recovery from inactivation at -70 mV was 10.5 times slower in beta-cells (60 ms) than in ACCs (5.7 ms). The rate of Na+-channel inactivation at physiological resting potential was more than three times slower in beta-cells than in ACCs. Na+ influx through Na+ channels had no effect on the secretory machinery in rat beta-cells. However, these 'silent Na+ channels' could contribute to the generation of action potentials in some conditions, such as when the cell is hyperpolarized. It is concluded that the fractional availability of Na+ channels in beta-cells at a holding potential of -70 mV is about 15% of that in ACCs. This value in rat beta-cells is larger than that observed in mouse (0%), but is smaller than those observed in human or dog (90%).
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2024
Appears in Collections:神经所(总)_期刊论文

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Lou, XL; Yu, X; Chen, XK; Duan, KL; He, LM; Qu, AL; Xu, T; Zhou, Z.Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat,JOURNAL OF PHYSIOLOGY-LONDON,2003,548(1):191-202
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