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Title: Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications
Author: Wang, ZR ; Xu, NL ; Wu, CP ; Duan, SM ; null(蒲慕明)
Source: NEURON
Issued Date: 2003
Volume: 37, Issue:3, Pages:463-472
Keyword: RAT HIPPOCAMPAL SLICES ; CA1 PYRAMIDAL NEURONS ; EPSP-SPIKE POTENTIATION ; E-S COMPONENT ; INTRINSIC EXCITABILITY ; SUPRALINEAR SUMMATION ; LASTING POTENTIATION ; PERFORANT PATH ; K+ CURRENT ; IN-VITRO
Subject: Neurosciences & Neurology
Corresponding Author: Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China,
English Abstract: Information processing in the neuron requires spatial summation of synaptic inputs at the dendrite. In CA1 pyramidal neurons of the hippocampus, a brief period of correlated pre- and postsynaptic activity, which induces long-term potentiation (LTP) or long-term depression (LTD), results in a persistent increase or decrease in the linearity of spatial summation, respectively. Such bidirectional modification of the summation property is specific to the modified input and reflects localized dendritic changes involving I-h channels and NMDA receptors. Thus, correlated pre- and postsynaptic activity alters not only the strength of the activated input but also its dendritic integration with other inputs.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2027
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

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Recommended Citation:
Wang, ZR; Xu, NL; Wu, CP; Duan, SM; Poo, MM.Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications,NEURON,2003,37(3):463-472
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