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Title: Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion
Author: Bao, L ; Jin, SX ; Zhang, C ; Wang, LH ; Xu, ZZ ; Zhang, FX ; Wang, LC ; Ning, FS ; Cai, HJ ; Guan, JS ; Xiao, HS ; Xu, ZQD ; He, C ; Hokfelt, T ; Zhou, Z ; null(张 旭)
Source: NEURON
Issued Date: 2003
Volume: 37, Issue:1, Pages:121-133
Keyword: GENE-RELATED PEPTIDE ; ADRENAL CHROMAFFIN CELLS ; CULTURED HIPPOCAMPAL-NEURONS ; PRIMARY AFFERENT-FIBERS ; RAT TRIGEMINAL NUCLEUS ; ROOT GANGLION NEURONS ; SPINAL-CORD INVIVO ; SUBSTANCE-P ; CA2+-DEPENDENT EXOCYTOSIS ; AMPA RECEPTORS
Subject: Neurosciences & Neurology
Corresponding Author: Zhou, Z (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Lab Sensory Syst, Shanghai, Peoples R China,
English Abstract: Here we describe a novel mechanism for plasma membrane insertion of the delta opioid receptor (DOR). In small dorsal root ganglion neurons, only low levels of DORs are present on the cell surface, in contrast to high levels of intracellular DORs mainly associated with vesicles containing calcitonin gene-related peptide (CGRP). Activation of surface DORs caused Ca2+ release from lP(3)-sensitive stores and Ca2+ entry, resulting in a slow and long-lasting exocytosis, DOR insertion, and CGRP release. In contrast, membrane depolarization or activation of vanilloid and P2Y, receptors induced a rapid DOR insertion. Thus, DOR activation induces a Ca2+-dependent insertion of DORs that is coupled to a release of excitatory neuropeptides, suggesting that treatment of inflammatory pain should include blockade of DORs.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2029
Appears in Collections:神经所(总)_期刊论文
感觉系统研究组_期刊论文

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Recommended Citation:
Bao, L; Jin, SX; Zhang, C; Wang, LH; Xu, ZZ; Zhang, FX; Wang, LC; Ning, FS; Cai, HJ; Guan, JS; Xiao, HS; Xu, ZQD; He, C; Hokfelt, T; Zhou, Z; Zhang, X.Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion,NEURON,2003,37(1):121-133
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