中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Signalling and crosstalk of Rho GTPases in mediating axon guidance
Author: Yuan, XB ; Jin, M ; Xu, XH ; Song, YQ ; Wu, CP ; null(蒲慕明) ; Duan, SM
Source: NATURE CELL BIOLOGY
Issued Date: 2003
Volume: 5, Issue:1, Pages:38-45
Keyword: MYOSIN-II ACTIVATION ; GROWTH CONE GUIDANCE ; NERVE GROWTH ; FAMILY GTPASES ; LYSOPHOSPHATIDIC ACID ; IN-VIVO ; KINASE ; PROTEIN ; PHOSPHORYLATION ; COLLAPSE
Subject: Cell Biology
Corresponding Author: Yuan, XB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,
English Abstract: Axon extension during development of the nervous system is guided by many factors, but the signalling mechanisms responsible for triggering this extension remain mostly unknown. Here we have examined the role of Rho family small guanosine triphosphatases (GTPases) in mediating axon guidance by diffusible factors. Expression of either dominant-negative or constitutively active Cdc42 in cultured Xenopus laevis spinal neurons, at a concentration that does not substantially affect filopodial formation and neurite extension, abolishes the chemoattractive growth cone turning induced by a gradient of brain-derived neurotrophic factor that can activate Cdc42 and Rac in cultured neurons. Chemorepulsion induced by a gradient of lysophosphatidic acid is also abolished by the expression of dominant-negative RhoA. We also show that an asymmetry in Rho kinase or filopodial initiation across the growth cone is sufficient to trigger the turning response and that there is a crosstalk between the Cdc42 and RhoA pathways through their converging actions on the myosin activity essential for growth cone chemorepulsion.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2033
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Yuan-2003-Signalling and cross.pdf(1450KB)----开放获取View Download

Recommended Citation:
Yuan, XB; Jin, M; Xu, XH; Song, YQ; Wu, CP; Poo, MM; Duan, SM.Signalling and crosstalk of Rho GTPases in mediating axon guidance,NATURE CELL BIOLOGY,2003,5(1):38-45
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yuan, XB]'s Articles
[Jin, M]'s Articles
[Xu, XH]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yuan, XB]‘s Articles
[Jin, M]‘s Articles
[Xu, XH]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Yuan-2003-Signalling and cross.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!