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Title: Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons
Author: He, LM ; Zhang, CG ; Zhou, Z ; Xu, T
Source: NEUROSCIENCE
Issued Date: 2003
Volume: 116, Issue:2, Pages:325-333
Keyword: corticosterone ; dorsal root ganglion ; calcium channel ; protein kinase C ; PROTEIN-KINASE-C ; N-TYPE ; CHANNEL BLOCKERS ; CA2+ CHANNEL ; PC12 CELLS ; P-TYPE ; GLUCOCORTICOIDS ; FORMALIN ; RELEASE ; DEXAMETHASONE
Subject: Neurosciences & Neurology
Corresponding Author: Xu, T (reprint author), Huazhong Univ Sci & Technol, Inst Biophys & Biochem, Wuhan 430074, Peoples R China,
English Abstract: Corticosterone may nongenomically affect cell functions in addition to its well-characterized effects on gene expression. The purpose of this study is to examine if corticosterone has a rapid nongenomic effect on excitability of dorsal root ganglion neurons by using patch-clamp and single-cell Ca2+ microfluometry techniques. The results show that corticosterone has a dose-dependent rapid inhibitory effect on the voltage-dependent calcium currents in dorsal root ganglion neurons. Moreover, corticosterone inhibits [Ca2+](i) elevation induced by 50 mM high K+ within just 3 s. The inhibitory effects of corticosterone on the voltage-dependent calcium current and high K+-induced calcium influx diminish after adding protein kinase C inhibitor or pretreatment with pertussis toxin for 24 h. Our results demonstrate an nongenomic effect of corticosterone on the excitability of dorsal root ganglion neurons and the effect is mediated through a putative pertussis toxin-sensitive G-protein-coupled receptor and activation of protein kinase C. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2035
Appears in Collections:神经所(总)_期刊论文

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He, LM; Zhang, CG; Zhou, Z; Xu, T.Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons,NEUROSCIENCE,2003,116(2):325-333
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