中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Interleukin-2 regulates membrane potentials and calcium channels via mu opioid receptors in rat dorsal root ganglion neurons
Author: Song, P ; Lie-Cheng, W ; Wang, GD ; Zhou, Z ; Zhao, ZQ
Source: NEUROPHARMACOLOGY
Issued Date: 2002
Volume: 43, Issue:8, Pages:1324-1329
Keyword: Ca2+ current ; [Ca2+]i ; dorsal root ganglion ; interleukin-2 ; intracellular recording ; whole-cell patch clamp ; SENSORY NEURONS ; HIGH-THRESHOLD ; CA2+ CURRENTS ; SPINAL-CORD ; RELEASE ; CELLS ; CA-2+ ; ANTINOCICEPTION ; MODULATION ; IL-2
Subject: Neurosciences & Neurology ; Pharmacology & Pharmacy
Corresponding Author: Zhao, ZQ (reprint author), Fudan Univ, Inst Neurobiol, 220 Han Dan Rd, Shanghai 200433, Peoples R China,
English Abstract: Our previous studies revealed that interleukin-2 (IL-2) exerted peripheral antinociception that was partially mediated by mu opioid receptors. No ionic explanations of this effect have yet been reported. The present study was designed to investigate effects of IL-2 on the physiological properties of capsaicin-sensitive small dorsal root ganglion (DRG) neurons, which are predominantly responsible for nociceptive transmission from the periphery to the spinal cord. Intracellualr recordings of DRG neurons were made in DRG/peripheral nerve preparation in vitro. IL-2 (10(3) U/ml) produced membrane hyperpolarization of -9.4 +/- 3.0 mV and this effect was blocked by beta-FNA (5 muM), a mu opioid receptor antagonist. Under whole-cell patch clamp recordings, transient high-threshold Ca2+ currents were inhibited by -56.6 +/- 11.3% by IL-2. Simultaneous calcium imaging showed that this cytokine also inhibited depolarization-evoked increase in intracellular calcium concentration. All the effects of IL-2 were blocked by naloxone (1 muM). Consistent with previous studies, DAMGO, a selective mu opioid agonist, exerted similar inhibitory effects on membrane potentials and Ca2+ currents. The present results indicated that g opioid receptors were involved in the regulatory effects of IL-2 on membrane potentials and calcium channels in DRG neurons, which may contribute to IL-2-induced peripheral analgesia. (C) 2002 Elsevier Science Ltd. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2038
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Song-2002-Interleukin-2 regula.pdf(101KB)----开放获取View Download

Recommended Citation:
Song, P; Lie-Cheng, W; Wang, GD; Zhou, Z; Zhao, ZQ.Interleukin-2 regulates membrane potentials and calcium channels via mu opioid receptors in rat dorsal root ganglion neurons,NEUROPHARMACOLOGY,2002,43(8):1324-1329
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Song, P]'s Articles
[Lie-Cheng, W]'s Articles
[Wang, GD]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Song, P]‘s Articles
[Lie-Cheng, W]‘s Articles
[Wang, GD]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Song-2002-Interleukin-2 regula.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!