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Title: Expression of fibroblast growth factors in rat dorsal root ganglion neurons and regulation after peripheral nerve injury
Author: Li, GD ; Wo, Y ; Zhong, MF ; Zhang, FX ; Bao, L ; Lu, YJ ; Huang, YD ; Xiao, HS ; null(张 旭)
Source: NEUROREPORT
Issued Date: 2002
Volume: 13, Issue:15, Pages:1903-1907
Keyword: axotomy ; cDNA array ; DRG ; expression ; FGF ; NEUROPEPTIDE-Y ; SPINAL-CORD ; IN-VITRO ; REGENERATION ; SYSTEM ; BFGF ; FGF ; LOCALIZATION ; SURVIVAL ; BDNF
Subject: Neurosciences & Neurology
Corresponding Author: Xiao, HS (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Lab Sensory Syst, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,
English Abstract: Using cDNA array, we observed the expression of eight members of the fibroblast growth factor (FGF) family, FGF 2, 5, 7,9,10,13 and 14, in rat lumbar 4 and 5 dorsal root ganglia (DRGs). Over a period of 28 days after sciatic nerve transection, the array signals for FGF 2 and 7 were significantly increased in the DRGs, while FGF 13 decreased. Using the reverse transcription polymerase chain reaction (RT-PCR), we confirmed the axotomy-induced changes in the expression of FGF 7 and 13. In situ hybridization showed that FGF 13 was expressed in 60% of DRG neurons under normal circumstance. Seven days after axotomy the number of FGF 13-positive neurons was decreased to 18%, but partially recovered to 40% after 28 days. FGF 13 immunoreactivity was also decreased. These data indicate that FGFs are important for DRG neurons under normal circumstance and after nerve injury.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2039
Appears in Collections:神经所(总)_期刊论文
感觉系统研究组_期刊论文

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Recommended Citation:
Li, GD; Wo, Y; Zhong, MF; Zhang, FX; Bao, L; Lu, YJ; Huang, YD; Xiao, HS; Zhang, X.Expression of fibroblast growth factors in rat dorsal root ganglion neurons and regulation after peripheral nerve injury,NEUROREPORT,2002,13(15):1903-1907
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