中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Nerve growth cone guidance mediated by G protein-coupled receptors
Author: Xiang, Y ; Li, Y ; Zhang, Z ; Cui, K ; Wang, S ; Yuan, XB ; Wu, CP ; null(蒲慕明) ; Duan, SM
Source: NATURE NEUROSCIENCE
Issued Date: 2002
Volume: 5, Issue:9, Pages:843-848
Keyword: NEURONAL MIGRATION ; AXON GUIDANCE ; LYMPHOCYTE CHEMOATTRACTANT ; PHOSPHOINOSITIDE 3-KINASE ; MOLECULAR-BIOLOGY ; CHEMOKINE ; SYSTEM ; CELLS ; CHEMOTAXIS ; NETRIN-1
Subject: Neurosciences & Neurology
Corresponding Author: Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,
English Abstract: Growing axons navigate by responding to chemical guidance cues. Here we report that growth cones of rat cerebellar axons in culture turned away from a gradient of SDF-1, a chemokine that attracts migrating leukocytes and cerebellar granule cells via a G protein-coupled receptor (GPCR). Similarly, Xenopus spinal growth cones turned away from a gradient of baclofen, an agonist of the GABA(B) receptor. This response was mediated by G(i) and subsequent activation of phospholipase C (PLC), which triggered two pathways: protein kinase C (PKC) led to repulsion, and inositol 1,4,5-triphosphate (IP3) receptor activation led to attractive turning. Under normal culture conditions, PKC-dependent repulsion dominated, but the repulsion could be converted to attraction by inhibiting PKC or by elevating cytosolic cGMP. Thus, GPCRs can mediate both repulsive and attractive axon guidance in vitro, and chemokines may serve as guidance cues for axon pathfinding.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2045
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Xiang-2002-Nerve growth cone gu.pdf(553KB)----开放获取View Download

Recommended Citation:
Xiang, Y; Li, Y; Zhang, Z; Cui, K; Wang, S; Yuan, XB; Wu, CP; Poo, MM; Duan, SM.Nerve growth cone guidance mediated by G protein-coupled receptors,NATURE NEUROSCIENCE,2002,5(9):843-848
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xiang, Y]'s Articles
[Li, Y]'s Articles
[Zhang, Z]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xiang, Y]‘s Articles
[Li, Y]‘s Articles
[Zhang, Z]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Xiang-2002-Nerve growth cone gu.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!