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Title: Regulation of AChR clustering by dishevelled interacting with MuSK and PAK1
Author: Luo, ZG ; Wang, Q ; Zhou, JZ ; Wang, JB ; Luo, ZJ ; Liu, MY ; He, X ; Wynshaw-Boris, A ; Xiong, WC ; Lu, B ; Mei, L
Source: NEURON
Issued Date: 2002
Volume: 35, Issue:3, Pages:489-505
Keyword: RECEPTOR TYROSINE KINASE ; NICOTINIC ACETYLCHOLINE-RECEPTOR ; NEUROMUSCULAR SYNAPSE FORMATION ; POLARITY GENE ; POSTSYNAPTIC APPARATUS ; JUXTAMEMBRANE REGION ; SIGNALING PATHWAYS ; SKELETAL-MUSCLE ; CELL POLARITY ; CRD DOMAIN
Subject: Neurosciences & Neurology
Corresponding Author: Mei, L (reprint author), Univ Alabama, Civitan Int Res Ctr, Dept Neurobiol, 1530 3rd Ave S, Birmingham, AL 35294 USA,
English Abstract: An important aspect of synapse development is the clustering of neurotransmitter receptors in the postsynaptic membrane. Although MuSK is required for acetylcholine receptor (AChR) clustering at the neuromuscular junction (NMJ), the underlying molecular mechanisms remain unclear. We report here that in muscle cells, MuSK interacts with Dishevelled (Dvl), a signaling molecule important for planar cell polarity. Disruption of the MuSK-Dvl interaction inhibits Agrin- and neuron-induced AChR clustering. Expression of dominant-negative Dvl1 in postsynaptic muscle cells reduces the amplitude of spontaneous synaptic currents at the NMJ. Moreover, Dvl1 interacts with downstream kinase PAK1. Agrin activates PAK, and this activation requires Dvl. Inhibition of PAK1 activity attenuates AChR clustering. These results demonstrate important roles of DO and PAK in Agrin/MuSK-induced AChR clustering and reveal a novel function of Dvl in synapse development.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2046
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Luo, ZG; Wang, Q; Zhou, JZ; Wang, JB; Luo, ZJ; Liu, MY; He, X; Wynshaw-Boris, A; Xiong, WC; Lu, B; Mei, L.Regulation of AChR clustering by dishevelled interacting with MuSK and PAK1,NEURON,2002,35(3):489-505
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