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Title: Ca2+-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons
Author: Zhang, C ; Zhou, Z
Source: NATURE NEUROSCIENCE
Issued Date: 2002
Volume: 5, Issue:5, Pages:425-430
Keyword: ADRENAL CHROMAFFIN CELLS ; TRANSMITTER RELEASE ; AMPEROMETRIC DETECTION ; QUANTAL SECRETION ; EXOCYTOSIS ; CATECHOLAMINES ; COMPETENT ; KINETICS ; PATHWAYS ; CALCIUM
Subject: Neurosciences & Neurology
Corresponding Author: Zhou, Z (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,zzhou@ion.ac.cn
English Abstract: We have investigated the Ca2+ dependence of vesicular secretion from the soma of dorsal root ganglion (DRG) neurons, which secrete neuropeptides by exocytosis of dense-core vesicles. In patch-clamped somata of rat DRG neurons, we found a depolarization-induced membrane capacitance increase (DeltaC(m)) in the absence of extracellular Ca2+ and in the presence of a Ca2+ chelator (BAPTA) in the intracellular solution. Depletion of internal Ca2+ stores by thapsigargin in the Ca2+-free bath also did not block the DeltaC(m), indicating that Ca2+ release from internal Ca2+ stores may not have been involved. Furthermore, the Ca2+-independent DeltaC(m) was blocked by whole-cell dialysis with tetanus toxin and was accompanied by pulsatile secretion of false transmitters, as detected by amperometric measurements. These results indicate the existence of Ca2+-independent but voltage-dependent vesicular secretion (CIVDS) in a mammalian sensory neuron.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2061
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Zhang, C; Zhou, Z.Ca2+-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons,NATURE NEUROSCIENCE,2002,5(5):425-430
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