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Title: GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons
Author: Yang, F ; Feng, LY ; Zheng, F ; Johnson, SW ; Du, J ; Shen, LY ; Wu, CP ; Lu, B
Source: NATURE NEUROSCIENCE
Issued Date: 2001
Volume: 4, Issue:11, Pages:1071-1078
Keyword: VENTRAL MESENCEPHALIC NEURONS ; MICE LACKING GDNF ; NEUROTROPHIC FACTOR ; NERVOUS-SYSTEM ; ELECTROPHYSIOLOGICAL PROPERTIES ; SYNAPTIC TRANSMISSION ; TYROSINE KINASE ; CATION CURRENT ; IN-VIVO ; RECEPTOR
Subject: Neurosciences & Neurology
Corresponding Author: Lu, B (reprint author), NICHHD, Unit Synapse Dev & Plast, LCSN, NIH, Bethesda, MD 20892 USA,
English Abstract: Glial cell line-derived neurotrophic factor (GDNF) prevents lesion-induced death of midbrain dopaminergic neurons, but its function in normal brain remains uncertain. Here we show that GDNF acutely and reversibly potentiated the excitability of cultured midbrain neurons by inhibiting transient A-type K+ channels. The effects of GDNF were limited to large, tyrosine hydroxylase (TH)positive dopaminergic neurons, and were mediated by mitogen associated protein (MAP) kinase. Application of GDNF also elicited a MAP kinase-dependent enhancement of the excitability in dopaminergic neurons in midbrain slice. These results demonstrate an acute regulation of GDNF on ion channels and its underlying signaling mechanism, and reveal an unexpected role of GDNF in normal midbrain dopaminergic neurons.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2069
Appears in Collections:神经所(总)_期刊论文

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Yang, F; Feng, LY; Zheng, F; Johnson, SW; Du, J; Shen, LY; Wu, CP; Lu, B.GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons,NATURE NEUROSCIENCE,2001,4(11):1071-1078
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