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Title: The expression of calcitonin gene-related peptide in dorsal horn neurons of the mouse lumbar spinal cord
Author: Tie-Jun, SS ; Xu, Z ; Hokfelt, T
Source: NEUROREPORT
Issued Date: 2001
Volume: 12, Issue:4, Pages:739-743
Keyword: dorsal root ganglia ; neuropeptide ; pain ; primary afferents ; sensory processing ; SENSORY NEURONS ; SUBSTANCE-P ; RAT ; NEUROPEPTIDES ; IMMUNOREACTIVITY ; GALANIN ; REFLEX ; TISSUE
Subject: Neurosciences & Neurology
Corresponding Author: Hokfelt, T (reprint author), Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden,
English Abstract: Using immunohistochemistry and in situ hybridization the expression of calcitonin gene-related peptide (CGRP) was studied in the mouse spinal cord under normal conditions and after unilateral rhizotomy and after local colchicine treatment. Under normal conditions a dense plexus of CGRP-immunoreactive (IR) fibres was observed in the superfical layers of dorsal horns with lower numbers of fibers in deeper laminae. Seven days after unilateral rhizotomy, there was a marked reduction of CGRP-IR fibres in the ipsilateral superfical layers and distinctly CGRP-IR neurons could be detected in the ipsilateral lamina III. CGRP mRNA-positive neurons were observed in lamina III in both the ipsilateral and contralateral dorsal horn. Colchicine treatment did not markedly increase the number of CGRP-IR neurons. The results suggest that CGRP is synthesized in local dorsal horn neurons of the mouse, and these neurons presumably participate in sensory processing. NeuroReport 12:739-743 (C) 2001 Lippincott Williams & Wilkins.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2077
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Tie-Jun, SS; Xu, Z; Hokfelt, T.The expression of calcitonin gene-related peptide in dorsal horn neurons of the mouse lumbar spinal cord,NEUROREPORT,2001,12(4):739-743
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