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Title: Glucose-induced Ca2+ signals in rat pancreatic beta cells
Author: Lou, XL ; Zeng, XH ; Qu, AL ; Zhou, Z
Source: PROGRESS IN NATURAL SCIENCE
Issued Date: 2001
Volume: 11, Issue:2, Pages:109-114
Keyword: rat pancreatic beta cell ; glucose ; calcium oscillation ; calcium stores ; SECRETION ; DECREASE
Subject: Materials Science ; Science & Technology - Other Topics
Corresponding Author: Zhou, Z (reprint author), Huazhong Univ Sci & Technol, Inst Biophys & Biochem, Wuhan 430074, Peoples R China,
English Abstract: Using microfluorometry to assay intracellular Ca2+, the influences of varied factors on glucose-induced Ca2+ signals, such as glucose-induced initial decline phase (GIDP), Ca2+ oscillation, and Ca2+ release from internal stores, were investigated in single rat pancreatic beta cells. Glucose was able to evoke GIDP even at non-stimulus concentration (5 mol/L), which is insufficient to induce Ca2+ spikes. GIDP was dependent on neither membrane depolarization nor extracellular Ca2+. However, GIDP was inhibited by thapsigargin, indicating a dependence on Ca2+ uptake by Ca2+ stores. The glucose-induced calcium oscillation was inhibited when external Ca2+ was removed. However, thapsigargin could not block the Ca2+ oscillation. These results suggest that maintenance of Ca2+ oscillation requires extracellular Ca2+ but not Ca2+ stores. Glucose was able to evoke Ca2+ signals even in the absence of external Ca2+. The glucose-induced Ca2+ release from intracellular Ca2+ stores was blocked by TTX. However, TTX had no effect on high K+-induced Ca2+ store release, suggesting that membrane depolarization can directly release Ca2+ from some internal Ca2+ stores in beta cells.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2080
Appears in Collections:神经所(总)_期刊论文

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Lou, XL; Zeng, XH; Qu, AL; Zhou, Z.Glucose-induced Ca2+ signals in rat pancreatic beta cells,PROGRESS IN NATURAL SCIENCE,2001,11(2):109-114
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