中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance
Author: Yuan, WL ; Zhou, LJ ; Chen, TH ; Wu, JY ; Rao, Y ; Ornitz, DM
Source: DEVELOPMENTAL BIOLOGY
Issued Date: 1999
Volume: 212, Issue:2, Pages:290-306
Keyword: NEURAL CREST MIGRATION ; NERVOUS-SYSTEM ; CNS MIDLINE ; MOLECULAR-CLONING ; LIMB DEVELOPMENT ; SPINAL-CORD ; MOTOR AXONS ; CHICK ; DROSOPHILA ; PROTEINS
Subject: Developmental Biology
Corresponding Author: Ornitz, DM (reprint author), Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, 660 S Euclid Ave, St Louis, MO 63110 USA,
English Abstract: The Slit gene encodes a secreted molecule essential for neural development in Drosophila embryos. Here we report the identification of three Slit homologues in the mouse. We demonstrate that the mouse SLIT1 protein can bind ROBO1, a transmembrane receptor implicated in axon guidance. Both whole-mount and section in situ hybridization studies reveal unique and complementary patterns of expression of the three mouse Slit genes and of Robo1, both within the central nervous system and in other developing tissues. The complementary expression patterns of Slit and Robo1 and their in vitro interaction suggest a ligand-receptor relationship. The expression of all three Slit genes in the floor plate suggests that they are likely to share the same functional properties with their Drosophila homologue in midline neural development and axon guidance. The complementary expression of Slit and Robo1 in different subdivisions of the somites suggests their possible function in axon pathfinding and neural crest cell migration. The unique expression pattern in Limb and other organs indicates additional potential functions of the Slit gene family. (C) 1999 Academic Press.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2099
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Yuan-1999-The mouse SLIT famil.pdf(1117KB)----开放获取View Download

Recommended Citation:
Yuan, WL; Zhou, LJ; Chen, TH; Wu, JY; Rao, Y; Ornitz, DM.The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance,DEVELOPMENTAL BIOLOGY,1999,212(2):290-306
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yuan, WL]'s Articles
[Zhou, LJ]'s Articles
[Chen, TH]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yuan, WL]‘s Articles
[Zhou, LJ]‘s Articles
[Chen, TH]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Yuan-1999-The mouse SLIT famil.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!