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Title: Directional guidance of neuronal migration in the olfactory system by the protein Slit
Author: Wu, W ; Wong, K ; Chen, JH ; Jiang, ZH ; Dupuls, S ; Wu, JY ; Rao, Y
Source: NATURE
Issued Date: 1999
Volume: 400, Issue:6742, Pages:331-336
Keyword: SUBVENTRICULAR ZONE CELLS ; NEURAL CREST MIGRATION ; FETAL MONKEY NEOCORTEX ; POLYSIALIC ACID ; NERVOUS-SYSTEM ; AXON GUIDANCE ; GENE ENCODES ; C-ELEGANS ; GLIA ; PRECURSORS
Subject: Science & Technology - Other Topics
Corresponding Author: Wu, JY (reprint author), Washington Univ, Sch Med, Dept Anat & Neurobiol, Box 8108,660 S Euclid Ave, St Louis, MO 63110 USA,
English Abstract: Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2100
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Wu, W; Wong, K; Chen, JH; Jiang, ZH; Dupuls, S; Wu, JY; Rao, Y.Directional guidance of neuronal migration in the olfactory system by the protein Slit,NATURE,1999,400(6742):331-336
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