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Title: Three GABA receptor-mediated postsynaptic potentials in interneurons in the rat lateral geniculate nucleus
Author: Zhu, JJ ; Lo, FS
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 1999
Volume: 19, Issue:14, Pages:5721-5730
Keyword: dendrite ; cortex ; visual cortex ; thalamus ; thalamic reticular nucleus ; lateral posterior nucleus ; superior colliculus ; inhibitory circuits ; oscillation ; epilepsy ; GABA(C) receptor ; retina ; POSTERIOR-PULVINAR COMPLEX ; DENDRO-DENDRITIC SYNAPSES ; GAMMA-AMINOBUTYRIC-ACID ; PATCH-CLAMP RECORDINGS ; CENTRAL-NERVOUS-SYSTEM ; IN-VITRO ; RELAY CELLS ; HORIZONTAL CELLS ; VISUAL-CORTEX ; BIPOLAR CELL
Subject: Neurosciences & Neurology
Corresponding Author: Zhu, JJ (reprint author), Cold Spring Harbor Lab, 1 Bungtown Rd,Jones Bldg, Cold Spring Harbor, NY 11724 USA,
English Abstract: Inhibition is crucial for the thalamus to relay sensory information from the periphery to the cortex and to participate in thalamocortical oscillations. However, the properties of inhibitory synaptic events in interneurons are poorly defined because in part of the technical difficulty of obtaining stable recording from these small cells. With the whole-cell recording technique, we obtained stable recordings from local interneurons in the lateral geniculate nucleus and studied their inhibitory synaptic properties. We found that interneurons expressed three different types of GABA receptors: bicuculline-sensitive GABA(A) receptors, bicuculline-insensitive GABA(A) receptors, and GABA(B) receptors. The reversal potentials of GABA responses were estimated by polarizing the membrane potential. The GABA(A) receptor-mediated responses had a reversal potential of approximately -82 mV, consistent with mediation via Cl- channels. The reversal potential for the GABA(B) response was -97 mV, consistent with it being a K+ conductance. The roles of these GABA receptors in postsynaptic responses were also examined in interneurons. Optic tract stimulation evoked a disynaptic IPSP that was mediated by all three types of GABA receptors and depended on activation of geniculate interneurons. Stimulation of the thalamic reticular nucleus evoked an IPSP, which appeared to be mediated exclusively by bicuculline-sensitive GABA(A) receptors and depended on the activation of reticular cells. The results indicate that geniculate interneurons form a complex neuronal circuitry with thalamocortical and reticular cells via feed-forward and feedback circuits, suggesting that they play a more important role in thalamic function than thought previously.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2103
Appears in Collections:神经所(总)_期刊论文

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Zhu, JJ; Lo, FS.Three GABA receptor-mediated postsynaptic potentials in interneurons in the rat lateral geniculate nucleus,JOURNAL OF NEUROSCIENCE,1999,19(14):5721-5730
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