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Title: Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
Author: Li, HS ; Chen, JH ; Wu, W ; Fagaly, T ; Zhou, LJ ; Yuan, WL ; Dupuis, S ; Jiang, ZH ; Nash, W ; Gick, C ; Ornitz, DM ; Wu, JY ; Rao, Y
Source: CELL
Issued Date: 1999
Volume: 96, Issue:6, Pages:807-818
Keyword: GROWTH CONE GUIDANCE ; ODORANT RECEPTOR EXPRESSION ; CENTRAL-NERVOUS-SYSTEM ; DORSAL-ROOT GANGLIA ; MITRAL TUFTED CELLS ; EMBRYO SPINAL-CORD ; C-ELEGANS ; COMMISSURAL AXONS ; MOTOR AXONS ; FLOOR-PLATE
Subject: Biochemistry & Molecular Biology ; Cell Biology
Corresponding Author: Wu, JY (reprint author), Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA,jwu@pharmdec.wustl.edu ; raoyi@thalamus.wustl.edu
English Abstract: The olfactory bulb plays a central role in olfactory information processing through its connections with both peripheral and cortical structures. Axons projecting from the olfactory bulb to the telencephalon are guided by a repulsive activity in the septum. The molecular nature of the repellent is not known. We report here the isolation of vertebrate homologs of the Drosophila slit gene and show that Slit protein binds to the transmembrane protein Roundabout (Robo). Slit is expressed in the septum whereas Robe is expressed in the olfactory bulb. Functionally, Slit acts as a chemorepellent for olfactory bulb axons. These results establish a ligand-receptor relationship between two molecules important for neural development, suggest a role for Slit in olfactory bulb axon guidance, and reveal the existence of a new family of axon guidance molecules.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2104
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Li, HS; Chen, JH; Wu, W; Fagaly, T; Zhou, LJ; Yuan, WL; Dupuis, S; Jiang, ZH; Nash, W; Gick, C; Ornitz, DM; Wu, JY; Rao, Y.Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons,CELL,1999,96(6):807-818
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