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Title: Activity-Induced Long-Term Potentiation of Excitatory Synapses in Developing Zebrafish Retina In Vivo
Author: Wei, HP ; Yao, YY ; Zhang, RW ; Zhao, XF ; null(杜久林)
Source: NEURON
Issued Date: 2012
Volume: 75, Issue:3, Pages:479-489
Keyword: GANGLION-CELL DENDRITES ; MEDIATED AFFERENT ACTIVITY ; ARACHIDONIC-ACID ; SYNAPTIC PLASTICITY ; BIPOLAR CELLS ; DEPENDENT PLASTICITY ; VISUAL DEPRIVATION ; MAMMALIAN RETINA ; RELEASE ; SYSTEM
Subject: Neurosciences & Neurology
Corresponding Author: Du, JL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,forestdu@ion.ac.cn
English Abstract: Neural activity-induced long-term potentiation (LTP) of synaptic transmission is believed to be one of the cellular mechanisms underlying experience-dependent developmental refinement of neural circuits. Although it is well established that visual experience and neural activity are critical for the refinement of retinal circuits, whether and how LTP occurs in the retina remain unknown. Using in vivo perforated whole-cell recording and two-photon calcium imaging, we find that both repeated electrical and visual stimulations can induce LTP at excitatory synapses formed by bipolar cells on retinal ganglion cells in larval but not juvenile zebrafish. LTP induction requires the activation of postsynaptic N-methyl-D-aspartate receptors, and its expression involves arachidonic acid-dependent presynaptic changes in calcium dynamics and neurotransmitter release. Physiologically, both electrical and visual stimulation-induced LIP can enhance visual responses of retinal ganglion cells. Thus, LIP exists in developing retinae with a presynaptic locus and may serve for visual experience-dependent refinement of retinal circuits.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2475
Appears in Collections:神经所(总)_期刊论文

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Wei, HP; Yao, YY; Zhang, RW; Zhao, XF; Du, JL.Activity-Induced Long-Term Potentiation of Excitatory Synapses in Developing Zebrafish Retina In Vivo,NEURON,2012,75(3):479-489
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