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Title: Enhancement of Asynchronous Release from Fast-Spiking Interneuron in Human and Rat Epileptic Neocortex
Author: Jiang, M ; Zhu, J ; Liu, YP ; Yang, MP ; Tian, CP ; Jiang, S ; Wang, YH ; Guo, H ; Wang, KY ; Shu, YS
Source: PLOS BIOLOGY
Issued Date: 2012
Volume: 10, Issue:5, Pages:-e1001324
Keyword: TEMPORAL-LOBE EPILEPSY ; TERM SYNAPTIC PLASTICITY ; DENTATE GRANULE CELLS ; ACTIVITY IN-VIVO ; TRANSMITTER RELEASE ; INHIBITORY INTERNEURONS ; REDUCED INHIBITION ; ENTORHINAL CORTEX ; PYRAMIDAL CELLS ; LAYER-III
Subject: Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
Corresponding Author: Wang, KY (reprint author), Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai 200433, Peoples R China.,wang_kaiyan@yahoo.com.cn ; shu@ion.ac.cn
English Abstract: Down-regulation of GABAergic inhibition may result in the generation of epileptiform activities. Besides spike-triggered synchronous GABA release, changes in asynchronous release (AR) following high-frequency discharges may further regulate epileptiform activities. In brain slices obtained from surgically removed human neocortical tissues of patients with intractable epilepsy and brain tumor, we found that AR occurred at GABAergic output synapses of fast-spiking (FS) neurons and its strength depended on the type of connections, with FS autapses showing the strongest AR. In addition, we found that AR depended on residual Ca2+ at presynaptic terminals but was independent of postsynaptic firing. Furthermore, AR at FS autapses was markedly elevated in human epileptic tissue as compared to non-epileptic tissue. In a rat model of epilepsy, we found similar elevation of AR at both FS autapses and synapses onto excitatory neurons. Further experiments and analysis showed that AR elevation in epileptic tissue may result from an increase in action potential amplitude in the FS neurons and elevation of residual Ca2+ concentration. Together, these results revealed that GABAergic AR occurred at both human and rat neocortex, and its elevation in epileptic tissue may contribute to the regulation of epileptiform activities.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2479
Appears in Collections:神经所(总)_期刊论文

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Jiang, M; Zhu, J; Liu, YP; Yang, MP; Tian, CP; Jiang, S; Wang, YH; Guo, H; Wang, KY; Shu, YS.Enhancement of Asynchronous Release from Fast-Spiking Interneuron in Human and Rat Epileptic Neocortex,PLOS BIOLOGY,2012,10(5):-e1001324
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