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Title: Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration
Author: Wu, QF ; Yang, L ; Li, S ; Wang, Q ; Yuan, XB ; Gao, X ; Bao, L ; null(张 旭)
Source: CELL
Issued Date: 2012
Volume: 149, Issue:7, Pages:1549-1564
Keyword: FACTOR HOMOLOGOUS FACTORS ; MULTIPOLAR STAGE ; NERVOUS-SYSTEM ; DOUBLECORTIN ; MICE ; OUTGROWTH ; MEMORY ; MAP1B ; NUCLEOKINESIS ; TRANSLOCATION
Subject: Biochemistry & Molecular Biology ; Cell Biology
Corresponding Author: Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn
English Abstract: Secretory fibroblast growth factors (FGFs) and their receptors are known for their regulatory function in the early stages of neural development. FGF13, a nonsecretory protein of the FGF family, is expressed in cerebral cortical neurons during development and is a candidate gene for syndromal and nonspecific forms of X-chromosome-linked mental retardation (XLMR). However, its function during development remains unclear. We show that FGF13 acts intracellularly as a microtubule-stabilizing protein required for axon and leading process development and neuronal migration in the cerebral cortex. FGF13 is enriched in axonal growth cones and interacts directly with microtubules. Furthermore, FGF13 polymerizes tubulins and stabilizes microtubules. The loss of FGF13 impairs neuronal polarization and increases the branching of axons and leading processes. Genetic deletion of FGF13 in mice results in neuronal migration defects in both the neocortex and the hippocampus. FGF13-deficient mice also exhibit weakened learning and memory, which is correlated to XLMR patients' intellectual disability.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2481
Appears in Collections:神经所(总)_期刊论文

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Wu, QF; Yang, L; Li, S; Wang, Q; Yuan, XB; Gao, X; Bao, L; Zhang, X.Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration,CELL,2012,149(7):1549-1564
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