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Title: Fstl1 Antagonizes BMP Signaling and Regulates Ureter Development
Author: Xu, JY ; Qi, X ; Gong, JF ; Yu, MY ; Zhang, FX ; Sha, HB ; Gao, X
Source: PLOS ONE
Issued Date: 2012
Volume: 7, Issue:4, Pages:-e32554
Keyword: BONE MORPHOGENETIC PROTEIN-4 ; URINARY-TRACT DEVELOPMENT ; SONIC-HEDGEHOG ; CONGENITAL-ANOMALIES ; MOUSE URETER ; BRANCHING MORPHOGENESIS ; PERISTALTIC MACHINERY ; VESICOURETERAL REFLUX ; KIDNEY DEVELOPMENT ; EXPRESSION
Subject: Science & Technology - Other Topics
Corresponding Author: Xu, JY (reprint author), Nanjing Univ, Model Anim Res Ctr, MOE Key Lab Model Anim Dis Study, Nanjing, Jiangsu, Peoples R China.,gaoxiang@nju.edu.cn
English Abstract: Bone morphogenetic protein (BMP) signaling pathway plays important roles in urinary tract development although the detailed regulation of its activity in this process remains unclear. Here we report that follistatiri-like 1 (Fstl1), encoding a secreted extracellular glycoprotein, is expressed in developing ureter and antagonizes BMP signaling activity. Mouse embryos carrying disrupted Fstl1 gene displayed prominent hydroureter arising from proximal segment and tireterovesical junction defects. These defects were associated with significant reduction in ureteric epithelial cell proliferation at E15.5 and E16.5 as well as absence of subepithelial ureteral mesenchymal cells in the urinary tract at E16.5 and E18.5. At the molecular level, increased BMP signaling was found in Fstl1 deficient ureters, indicated by elevated pSmad1/5/8 activity. in vitro study also indicated that Fstl1 can directly bind to ALK6 which is specifically expressed in ureteric epithelial cells in developing ureter. Furthermore, Sonic hedgehog (SHH) signaling, which is crucial for differentiation of ureteral subepithelial cell proliferation, was also impaired in Fstl1(-/-) ureter. Altogether, our data suggest that Fstl1 is essential in maintaining normal ureter development by antagonizing BMP signaling.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2483
Appears in Collections:神经所(总)_期刊论文

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Xu, JY; Qi, X; Gong, JF; Yu, MY; Zhang, FX; Sha, HB; Gao, X.Fstl1 Antagonizes BMP Signaling and Regulates Ureter Development,PLOS ONE,2012,7(4):-e32554
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