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Title: Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons
Author: null(张 旭) ; Bao, L
Source: NEUROSCIENCE BULLETIN
Issued Date: 2012
Volume: 28, Issue:2, Pages:121-130
Keyword: DORSAL-ROOT GANGLIA ; PROTEIN-COUPLED RECEPTORS ; DENSE-CORE VESICLES ; RAT SPINAL-CORD ; MORPHINE-TOLERANCE ; MESSENGER-RNAS ; KNOCKOUT MICE ; AUTORADIOGRAPHIC LOCALIZATION ; PHYSICAL-DEPENDENCE ; PERIPHERAL AXOTOMY
Subject: Neurosciences & Neurology
Corresponding Author: Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn
English Abstract: mu-opioid receptor (MOR) agonists such as morphine are powerful analgesics used for pain therapy. However, the use of these drugs is limited by their side-effects, which include antinociceptive tolerance and dependence. Earlier studies reported that MOR analgesic tolerance is reduced by blockade of delta-opioid receptors (DORs) that interact with MORs. Recent studies show that the MOR/DOR interaction in nociceptive afferent neurons in the dorsal root ganglion may contribute to morphine analgesic tolerance. Further analysis of the mechanisms for regulating the trafficking of receptors, ion channels and signaling molecules in nociceptive afferent neurons would help to understand the nociceptive mechanisms and improve pain therapy.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2486
Appears in Collections:神经所(总)_期刊论文

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Zhang, X; Bao, L.Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons,NEUROSCIENCE BULLETIN,2012,28(2):121-130
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