中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Mutation of Drosophila dopamine receptor DopR leads to male-male courtship behavior
Author: Chen, B ; Liu, H ; Ren, J ; null(郭爱克)
Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Issued Date: 2012
Volume: 423, Issue:3, Pages:557-563
Keyword: CENTRAL-NERVOUS-SYSTEM ; MELANOGASTER ; FRUITLESS ; GENE ; EXPRESSION ; AROUSAL ; NEURONS ; FLY
Subject: Biochemistry & Molecular Biology ; Biophysics
Corresponding Author: Guo, AK (reprint author), Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, Beijing, Peoples R China.,akguo@ion.ac.cn
English Abstract: In Drosophila, dopamine plays important roles in many biological processes as a neuromodulator. Previous studies showed that dopamine level could affect fly courtship behaviors. Disturbed dopamine level leads to abnormal courtship behavior in two different ways. Dopamine up-regulation induces male-male courtship behavior, while down-regulation of dopamine level results in increased sexual attractiveness of males towards other male flies. Until now, the identity of the dopamine receptor involved in this abnormal male-male courtship behavior remains unknown. Here we used genetic approaches to investigate the role of dopamine receptors in fly courtship behavior. We found that a dopamine D-1-like receptor, DopR, was involved in fly courtship behavior. DopR mutant male flies display male-male courtship behavior. This behavior is mainly due to the male's increased propensity to court other males. Expression of functional DopR successfully rescued this mutant phenotype. Knock-down of D-2-like receptor D2R and another D-1-like receptor, DAMB, did not induce male-male courtship behavior, indicating the receptor-type specificity of this phenomenon. Our findings provide insight into a possible link between dopamine level disturbance and the induced male-male courtship behavior. (C) 2012 Elsevier Inc. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2490
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Chen-2012-Mutation of Drosophi.pdf(545KB)----开放获取View Download

Recommended Citation:
Chen, B; Liu, H; Ren, J; Guo, AK.Mutation of Drosophila dopamine receptor DopR leads to male-male courtship behavior,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,423(3):557-563
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, B]'s Articles
[Liu, H]'s Articles
[Ren, J]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, B]‘s Articles
[Liu, H]‘s Articles
[Ren, J]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Chen-2012-Mutation of Drosophi.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!