中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: P-4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth
Author: Xu, Q ; Yang, GY ; Liu, N ; Xu, P ; Chen, YL ; Zhou, Z ; Luo, ZG ; Ding, XY
Source: FEBS LETTERS
Issued Date: 2012
Volume: 586, Issue:13, Pages:1803-1812
Keyword: P-TYPE ATPASE ; NERVE GROWTH-FACTOR ; PHOSPHOLIPID TRANSLOCATION ; SUBCELLULAR-LOCALIZATION ; SACCHAROMYCES-CEREVISIAE ; DRS2P ; PROTEIN ; DIFFERENTIATION ; IDENTIFICATION ; ESTABLISHMENT
Subject: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
Corresponding Author: Ding, XY (reprint author), Chinese Acad Sci, Grad Sch, State Key Lab Cell Biol, Inst Biochem & Cell Biol,SIBS, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xyding@sibs.ac.cn
English Abstract: P-4-ATPases are lipid flippases that transport phospholipids across cellular membranes, playing vital roles in cell function. In humans, the disruption of the P-4-ATPase ATP8A2 gene causes a severe neurological phenotype. Here, we found that Atp8a2 mRNA was highly expressed in PC12 cells, hippocampal neurons and the brain. Overexpression of ATP8A2 increased the length of neurite outgrowth in NGF-induced PC12 cells and in primary cultures of rat hippocampal neurons. Inducing the loss of function of CDC50A in hippocampal neurons via RNA interference reduced neurite outgrowth, and the co-overexpression of CDC50A and ATP8A2 in PC12 cells enhanced NGF-induced neurite outgrowth. These results indicate that ATP8A2, acting in synergy with CDC50A, performs an important role in neurite outgrowth in neurons. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2493
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Xu-2012-P-4-ATPase ATP8A2 ac.pdf(1457KB)----开放获取View Download

Recommended Citation:
Xu, Q; Yang, GY; Liu, N; Xu, P; Chen, YL; Zhou, Z; Luo, ZG; Ding, XY.P-4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth,FEBS LETTERS,2012,586(13):1803-1812
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xu, Q]'s Articles
[Yang, GY]'s Articles
[Liu, N]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xu, Q]‘s Articles
[Yang, GY]‘s Articles
[Liu, N]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Xu-2012-P-4-ATPase ATP8A2 ac.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!