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Title: Proton production, regulation and pathophysiological roles in the mammalian brain
Author: Zeng, WZ ; Xu, TL
Source: NEUROSCIENCE BULLETIN
Issued Date: 2012
Volume: 28, Issue:1, Pages:1-13
Keyword: SENSING ION CHANNELS ; GABA(A) RECEPTOR TRAFFICKING ; GATED CALCIUM-CHANNELS ; CENTRAL-NERVOUS-SYSTEM ; LONG-TERM-MEMORY ; H EXCHANGER NHE1 ; INTRACELLULAR PH ; MOLECULAR-BASIS ; CELL-MIGRATION ; SNAIL NEURONS
Subject: Neurosciences & Neurology
Corresponding Author: Xu, TL (reprint author), Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Neurosci Div,Dept Biochem & Mol Cell Biol, Shanghai 200025, Peoples R China.,xu-happiness@shsmu.edu.cn
English Abstract: The recent demonstration of proton signaling in C. elegans muscle contraction suggests a novel mechanism for proton-based intercellular communication and has stimulated enthusiasm for exploring proton signaling in higher organisms. Emerging evidence indicates that protons are produced and regulated in localized space and time. Furthermore, identification of proton regulators and sensors in the brain leads to the speculation that proton production and regulation may be of major importance for both physiological and pathological functions ranging from nociception to learning and memory. Extracellular protons may play a role in signal transmission by not only acting on adjacent cells but also affecting the cell from which they were released. In this review, we summarize the upstream and downstream pathways of proton production and regulation in the mammalian brain, with special emphasis on the proton extruders and sensors that are critical in the homeostatic regulation of pH, and discuss their potential roles in proton signaling under normal and pathophysiological conditions.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2496
Appears in Collections:神经所(总)_期刊论文

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Zeng, WZ; Xu, TL.Proton production, regulation and pathophysiological roles in the mammalian brain,NEUROSCIENCE BULLETIN,2012,28(1):1-13
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