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Title: Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo
Author: Li, Y ; Du, XF ; Liu, CS ; Wen, ZL ; null(杜久林)
Source: DEVELOPMENTAL CELL
Issued Date: 2012
Volume: 23, Issue:6, Pages:1189-1202
Keyword: BRAIN ; ZEBRAFISH ; CELLS ; REVEALS ; CNS ; MACROPHAGES ; ACTIVATION ; PARENCHYMA ; EXPRESSION ; APOPTOSIS
Subject: Cell Biology ; Developmental Biology
Corresponding Author: Du, JL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,forestdu@ion.ac.cn
English Abstract: Microglia are the primary immune cells in the brain. Under physiological conditions, they typically stay in a "resting" state, with ramified processes continuously extending to and retracting from surrounding neural tissues. Whether and how such highly dynamic resting microglia functionally interact with surrounding neurons are still unclear. Using in vivo time-lapse imaging of both microglial morphology and neuronal activity in the optic tectum of larval zebrafish, we found that neuronal activity steers resting microglial processes and facilitates their contact with highly active neurons. This process requires the activation of pannexin-1 hemichannels on neurons. Reciprocally, such resting microglia-neuron contact reduces both spontaneous and visually evoked activities of contacted neurons. Our findings reveal an instructive role for neuronal activity in resting microglial motility and suggest the function for microglia in homeostatic regulation of neuronal activity in the healthy brain.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2497
Appears in Collections:神经所(总)_期刊论文

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Li, Y; Du, XF; Liu, CS; Wen, ZL; Du, JL.Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo,DEVELOPMENTAL CELL,2012,23(6):1189-1202
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