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Title: Thrombin Receptor Regulates Hematopoiesis and Endothelial-to-Hematopoietic Transition
Author: Yue, R ; Li, HS ; Liu, H ; Li, YY ; Wei, B ; Gao, G ; Jin, Y ; Liu, TX ; Wei, LP ; null(杜久林) ; Pei, G
Source: DEVELOPMENTAL CELL
Issued Date: 2012
Volume: 22, Issue:5, Pages:1092-1100
Keyword: PROTEASE-ACTIVATED RECEPTORS ; EPITHELIAL-CELL PLASTICITY ; STEM-CELLS ; DEFINITIVE HEMATOPOIESIS ; EMBRYONIC-DEVELOPMENT ; AORTIC ENDOTHELIUM ; COUPLED RECEPTORS ; HAEMOGENIC ENDOTHELIUM ; ZEBRAFISH EMBRYO ; RHO-GTPASES
Subject: Cell Biology ; Developmental Biology
Corresponding Author: Pei, G (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci,Grad Sch, Shanghai 200031, Peoples R China.,gpei@sibs.ac.cn
English Abstract: Hematopoietic development and vascular development are closely related physiological processes during vertebrate embryogenesis. Recently, endothelial-to-hematopoietic transition (EHT) was demonstrated to be critical for hematopoietic stem and progenitor cell induction, but its underlying regulatory mechanisms remain poorly understood. Here we show that thrombin receptor (F2r), a protease-activated G protein-coupled receptor required for vascular development, functions as a negative regulator during hematopoietic development. F2r is significantly upregulated during hematopoietic differentiation of mouse embryonic stem cells (mESCs) and zebrafish hematopoietic development. Pharmacological or genetic inhibition of F2r promotes hematopoietic differentiation, whereas F2r overexpression shows opposite effects. Further mechanistic studies reveal that F2r-RhoA/ROCK pathway inhibits EHT in vitro and negatively regulates zebrafish EHT and hematopoietic stem cell induction in vivo. Taken together, this study demonstrates a fundamental role of F2r-RhoA/ROCK pathway in vertebrate hematopoiesis and EHT, as well as an important molecular mechanism coordinating hematopoietic and vascular development.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2505
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Yue, R; Li, HS; Liu, H; Li, YY; Wei, B; Gao, G; Jin, Y; Liu, TX; Wei, LP; Du, JL; Pei, G.Thrombin Receptor Regulates Hematopoiesis and Endothelial-to-Hematopoietic Transition,DEVELOPMENTAL CELL,2012,22(5):1092-1100
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