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Title: Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism
Author: Mu, Y ; Li, XQ ; Zhang, B ; null(杜久林)
Source: NEURON
Issued Date: 2012
Volume: 75, Issue:4, Pages:688-699
Keyword: TO-NOISE RATIO ; MULTISENSORY INTEGRATION ; LARVAL ZEBRAFISH ; AUDITORY-CORTEX ; MAUTHNER CELL ; TYROSINE-HYDROXYLASE ; SUPERIOR COLLICULUS ; SENSORY RESPONSES ; CEREBRAL-CORTEX ; MIXED SYNAPSES
Subject: Neurosciences & Neurology
Corresponding Author: Du, JL (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,forestdu@ion.ac.cn
English Abstract: Visual cues often modulate auditory signal processing, leading to improved sound detection. However, the synaptic and circuit mechanism underlying this cross-modal modulation remains poorly understood. Using larval zebrafish, we first established a cross-modal behavioral paradigm in which a preceding flash enhances sound-evoked escape behavior, which is known to be executed through auditory afferents (VIIIth nerves) and command-like neurons (Mauthner cells). In vivo recording revealed that the visual enhancement of auditory escape is achieved by increasing sound-evoked Mauthner cell responses. This increase in Mauthner cell responses is accounted for by the increase in the signal-to-noise ratio of sound-evoked VIIIth nerve spiking and efficacy of VIIIth nerve-Mauthner cell synapses. Furthermore, the visual enhancement of Mauthner cell response and escape behavior requires light-responsive dopaminergic neurons in the caudal hypothalamus and D1 dopamine receptor activation. Our findings illustrate a cooperative neural mechanism for visual modulation of audiomotor processing that involves dopaminergic neuromodulation.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2510
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Mu, Y; Li, XQ; Zhang, B; Du, JL.Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism,NEURON,2012,75(4):688-699
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