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Title: Analysis of a Gene Regulatory Cascade Mediating Circadian Rhythm in Zebrafish
Author: Li, Y ; Li, G ; Wang, HF ; null(杜久林) ; Yan, J
Source: PLOS COMPUTATIONAL BIOLOGY
Issued Date: 2013
Volume: 9, Issue:2, Pages:-e1002940
Keyword: TRANSCRIPTION FACTOR ; CLOCK ; EXPRESSION ; LIGHT ; REVEALS ; NEUROSPORA ; PATHWAYS ; CELLS ; MOUSE ; CRX
Subject: Biochemistry & Molecular Biology ; Mathematical & Computational Biology
Corresponding Author: Yan, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China.,junyan@picb.ac.cn
English Abstract: In the study of circadian rhythms, it has been a puzzle how a limited number of circadian clock genes can control diverse aspects of physiology. Here we investigate circadian gene expression genome-wide using larval zebrafish as a model system. We made use of a spatial gene expression atlas to investigate the expression of circadian genes in various tissues and cell types. Comparison of genome-wide circadian gene expression data between zebrafish and mouse revealed a nearly anti-phase relationship and allowed us to detect novel evolutionarily conserved circadian genes in vertebrates. We identified three groups of zebrafish genes with distinct responses to light entrainment: fast light-induced genes, slow light-induced genes, and dark-induced genes. Our computational analysis of the circadian gene regulatory network revealed several transcription factors (TFs) involved in diverse aspects of circadian physiology through transcriptional cascade. Of these, microphthalmia-associated transcription factor a (mitfa), a dark-induced TF, mediates a circadian rhythm of melanin synthesis, which may be involved in zebrafish's adaptation to daily light cycling. Our study describes a systematic method to discover previously unidentified TFs involved in circadian physiology in complex organisms.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2515
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Li, Y; Li, G; Wang, HF; Du, JL; Yan, J.Analysis of a Gene Regulatory Cascade Mediating Circadian Rhythm in Zebrafish,PLOS COMPUTATIONAL BIOLOGY,2013,9(2):-e1002940
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