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Title: Heterosynaptic long-term depression mediated by ATP released from astrocytes
Author: Chen, JD ; Tan, ZB ; Zeng, L ; Zhang, XX ; He, Y ; Gao, W ; Wu, XM ; Li, YJ ; Bu, BT ; Wang, W ; Duan, SM
Source: GLIA
Issued Date: 2013
Volume: 61, Issue:2, Pages:178-191
Keyword: CULTURED HIPPOCAMPAL-NEURONS ; GLIAL-CELLS ; SYNAPTIC-TRANSMISSION ; D-SERINE ; GLUTAMATE RELEASE ; CALCIUM WAVES ; POTENTIATION ; STIMULATION ; PLASTICITY ; RECEPTOR
Subject: Neurosciences & Neurology
Corresponding Author: Duan, SM (reprint author), Zhejiang Univ, Sch Med, Key Lab Neurobiol Zhejiang Prov, Minist Hlth China,Dept Neurobiol,Key Lab Med Neur, Hangzhou 310003, Zhejiang, Peoples R China.,duanshumin@zju.edu.cn
English Abstract: Heterosynaptic long-term depression (hLTD) at untetanized synapses accompanying the induction of long-term potentiation (LTP) spatially sharpens the activity-induced synaptic potentiation; however, the underlying mechanism remains unclear. We found that hLTD in the hippocampal CA1 region is caused by stimulation-induced ATP release from astrocytes that suppresses transmitter release from untetanized synaptic terminals via activation of P2Y receptors. Selective stimulation of astrocytes expressing channelrhodopsin-2, a light-gated cation channel permeable to Ca2+, resulted in LTD of synapses on neighboring neurons. This synaptic modification required Ca2+ elevation in astrocytes and activation of P2Y receptors, but not N-methyl-D-aspartate receptors. Furthermore, blocking P2Y receptors or buffering astrocyte intracellular Ca2+ at a low level prevented hLTD without affecting LTP induced by SC stimulation. Thus, astrocyte activation is both necessary and sufficient for mediating hLTD accompanying LTP induction, strongly supporting the notion that astrocytes actively participate in activity-dependent synaptic plasticity of neural circuits. (c) 2012 Wiley Periodicals, Inc.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2517
Appears in Collections:神经所(总)_期刊论文

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Chen, JD; Tan, ZB; Zeng, L; Zhang, XX; He, Y; Gao, W; Wu, XM; Li, YJ; Bu, BT; Wang, W; Duan, SM.Heterosynaptic long-term depression mediated by ATP released from astrocytes,GLIA,2013,61(2):178-191
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